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KMID : 0366220070420040428
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Korean Journal of Hematology
2007 Volume.42 No. 4 p.428 ~ p.432
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A Case of Acute Promyelocytic Leukemia with PML/RARA Translocation Showing Familial t(9;15)(q34;q22)
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Shin So-Yeon
Koo Sun-Hoe
Kwon Kye-Chul
Park Jong-Woo
Ko Chi-Seon
Jo Deog-Yeon
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Abstract
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We report the unusual case of an APL patient with a familial t(9;15)(q34;q22) and acquired t(15;17) (q22;q21). This is unique in that the patient had a constitutional abnormality with the same breakpoints as those observed in the tumor clone from the APL. It is unclear if the breakpoint, 15q22, in the constitutional aberration influenced the induction of the PML/RARA translocation in the APL. If a specific translocation in a patient with leukemia does not go away with clinical improvement, a congenital or familial chromosomal abnormality should be considered. Additional patients with similar findings are needed to understand the pathogenesis of these events. (Korean J Hematol 2007;42:428-432.)
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KEYWORD
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Acute promyelocytic leukemia, Chromosomal translocation, t(9, 15), t(15, 17), Constitutional chromosomal abnormality
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